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The Saints have won back to back games after blowing out the Giants 24-6 at the Superdome.
Derek Carr completed 23 of his 28 pass attempts for 218 yards and three touchdowns.
Alvin Kamara ran for 66 yards on 16 carries and also caught five passes for 44 yards.
Juwan Johnson, Jimmy Graham and Keith Kirkwood each caught a touchdown pass, as New Orleans is sitting second in the NFC South at 7-7.
The Saints head out west to challenge the Los Angeles Rams on Thursday Night Football.
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